Kanaka CYP2C19 Gene Polymorphism

ʻO CYP2C19 kekahi o nā enzyme metabolizing lāʻau nui i ka ʻohana CYP450.ʻO ka nui o nā substrates endogenous a ma kahi o 2% o nā lāʻau lapaʻau e hoʻololi ʻia e CYP2C19, e like me ka metabolism o ka antiplatelet aggregation inhibitors (e like me clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, a pēlā aku. lāʻau pili.ʻO kēia mau helu hoʻololi o *2 (rs4244285) a me *3 (rs4986893) ke kumu i ka nalowale o ka hana enzyme i hoʻopaʻa ʻia e ka CYP2C19 gene a me ka nāwaliwali o ka hiki ke substrate metabolic, a hoʻonui i ka neʻe ʻana o ke koko, i mea e hoʻopilikia ai i ka lāʻau lapaʻau. hoʻopaʻa koko.*17 (rs12248560) hiki ke hoʻonui i ka hana enzyme i hoʻopaʻa ʻia e CYP2C19 gene, ka hana ʻana o nā metabolites ikaika, a hoʻonui i ka pale ʻana i ka platelet aggregation a hoʻonui i ka pilikia o ke koko.No ka poʻe me ka lohi o ka metabolism o nā lāʻau lapaʻau, ʻo ka lawe ʻana i nā maʻi maʻamau no ka manawa lōʻihi e hoʻoulu ai i nā hopena koʻikoʻi a me nā hopena ʻaoʻao: ʻo ka nui o ka pōʻino o ka ate, ka pōʻino o ka ʻōnaehana hematopoietic, ka pōʻino o ka ʻōnaehana nerve waena, etc., hiki ke alakaʻi i ka make i nā hihia koʻikoʻi.Wahi a nā ʻokoʻa o kēlā me kēia kanaka i ka lāʻau lapaʻau e pili ana, ua māhele ʻia i ʻehā phenotypes, ʻo ia hoʻi ka ultra-fast metabolism (UM,*17/*17,*1/*17), fast metabolism (RM,*1/*1 ), ka hoʻokele waena (IM, *1/*2, *1/*3), ka hoʻokaʻawale lohi (PM, *2/*2, *2/*3, *3/*3).