Kanaka EGFR Gene 29 Mutations

ʻO ka wehewehe pōkole:

Hoʻohana ʻia kēia pahu i ka in vitro qualitatively detection of common mutations in exons 18-21 of the EGFR gene in samples from non-liʻiliʻi cell lung cancer maʻi.


Huahana Huahana

Huahana Huahana

Inoa mea kūʻai

HWTS-TM001A-Human EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR)

Epidemiology

Ua lilo ka ma'i 'a'ai 'o ke kumu nui o ka make 'ana o ka ma'i 'a'ai ma ka honua holo'oko'a, e ho'oweliweli nui ana i ke ola kanaka.ʻO ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi ma kahi o 80% o nā maʻi maʻi maʻi maʻi.ʻO EGFR i kēia manawa ka pahuhopu molekala nui loa no ka mālama ʻana i ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi.Hiki i ka phosphorylation o EGFR ke hoʻoikaika i ka ulu ʻana o ka cell tumor, ka ʻokoʻa, ka hoʻouka ʻana, ka metastasis, ka anti-apoptosis, a me ka hoʻoikaika ʻana i ka angiogenesis tumor.Hiki i ka EGFR tyrosine kinase inhibitors (TKI) ke ālai i ke ala hōʻailona EGFR ma ke kāohi ʻana i ka autophosphorylation EGFR, ma laila e pale ai i ka hoʻonui a me ka hoʻokaʻawale ʻana o nā cell tumor, e hāpai ana i ka apoptosis cell tumor, e hōʻemi ana i ka angiogenesis tumor, etc.Ua hōʻike ʻia kahi helu nui o nā haʻawina e pili pono ana ka therapeutic efficacy o EGFR-TKI i ke kūlana o ka mutation gene EGFR, a hiki ke pale pono i ka ulu ʻana o nā pūnaewele tumora me ka mutation gene EGFR.Aia ka gene EGFR ma ka lima pōkole o ka chromosome 7 (7p12), me ka lōʻihi piha o 200Kb a he 28 exons.Aia ka ʻāina mutated i nā exons 18 a i 21, codons 746 a 753 hoʻopau ʻana i ka mutation ma exon 19 mau helu no kahi 45% a me ka L858R mutation ma exon 21 mau helu no kahi 40% a 45%.ʻO ka NCCN Guidelines for the Diagnosis and Treatment of Non-Small Cell Lung Cancer e hōʻike maopopo ana he pono ka hoʻāʻo ʻana o ka gene mutation EGFR ma mua o ka hoʻokele EGFR-TKI.Hoʻohana ʻia kēia pahu hoʻāʻo e alakaʻi i ka hoʻokele ʻana i nā lāʻau epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), a hāʻawi i ke kumu no ka lāʻau lapaʻau pilikino no nā poʻe maʻi me ka maʻi maʻi ʻaʻa ʻole liʻiliʻi.Hoʻohana wale ʻia kēia pahu no ka ʻike ʻana i nā hoʻololi maʻamau i ka gene EGFR i nā poʻe maʻi me ka maʻi maʻi ʻaʻai liʻiliʻi liʻiliʻi.ʻO nā hopena hōʻike no ka hōʻike lapaʻau wale nō a ʻaʻole pono e hoʻohana ʻia ma ke kumu hoʻokahi no ka mālama ʻana i nā maʻi.Pono nā kauka lapaʻau e noʻonoʻo i ke kūlana o ka mea maʻi, nā hōʻailona lāʻau, a me ka mālama ʻana.

Kanal

FAM Hoʻopaʻa IC, L858R Reaction Buffer, 19del Reaction Buffer, T790M Reaction Buffer, G719X Reaction Buffer, 3Ins20 Reaction Buffer, L861Q Reaction Buffer, S768I Reaction Buffer

Nā ʻāpana ʻenehana

Waihona Ka wai: ≤-18 ℃ I ka pōʻeleʻele;Lyophilized: ≤30 ℃ I ka pōʻeleʻele
Kau-ola Ka wai: 9 mahina;Lyophilized: 12 mahina
ʻAno Hoʻohālike ʻiʻo maʻi maʻi hou, ʻāpana pathological maloʻo, ʻiʻo pathological i hoʻokomo ʻia i ka paraffin a ʻāpana paha, plasma a i ʻole serum
CV <5.0%
LoD ka ʻike ʻana i ka hopena hopena nucleic acid ma lalo o ke kāʻei o 3ng/μL wild-type, hiki ke ʻike paʻa i ka 1% mutation rate.
kikoo ʻAʻohe hana keʻa me ka DNA genomic kanaka ʻano hihiu a me nā ʻano mutant ʻē aʻe
Nā mea hana pili Hoʻohana ʻia Biosystems 7500 Pūnaehana PCR manawa maoliHoʻohana ʻia Biosystems 7300 Pūnaehana PCR manawa maoli

QuantStudio® 5 Pūnaehana PCR Manawa maoli

LightCycler® 480 Pūnaehana PCR manawa maoli

BioRad CFX96 Pūnaehana PCR Manawa maoli

Holo Hana

5a96c5434dc358f19d21fe988959493


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