ʻO Mei 17, 2023 ka 19th "World Hypertension Day".
Ua ʻike ʻia ka hypertension ma ke ʻano he "pepehi" o ke olakino kanaka.ʻOi aku ma mua o ka hapalua o nā maʻi cardiovascular, stroke a me ka pau ʻole o ka naʻau ma muli o ka hypertension.No laila, he ala lōʻihi kā mākou e hele ai i ka pale ʻana a me ka mālama ʻana i ka hypertension.
01 Ka laha nui o ke ao holookoa o ka hypertension
Ma ke ao holoʻokoʻa, ma kahi o 1.28 biliona kanaka makua mai 30-79 mau makahiki i loaʻa i ke koko kiʻekiʻe.ʻO 42% wale nō o nā poʻe maʻi me ke kiʻekiʻe kiʻekiʻe i ʻike ʻia a mālama ʻia, a ma kahi o hoʻokahi i loko o ʻelima mau maʻi i mālama ʻia ko lākou hypertension.I ka makahiki 2019, ua ʻoi aku ka nui o nā make ma muli o ka hypertension ma ka honua holoʻokoʻa ma mua o 10 miliona, e helu ana ma kahi o 19% o nā make āpau.
02 He aha ka hypertension?
ʻO ke kiʻekiʻe kiʻekiʻe kahi maʻi maʻi cardiovascular i hōʻike ʻia e ka piʻi mau ʻana o ke kiʻekiʻe o ke koko i loko o nā kīʻaha arterial.
ʻO ka hapa nui o nā maʻi ʻaʻohe hōʻailona maopopo a hōʻailona paha.Hiki i kekahi helu liʻiliʻi o ka poʻe maʻi hypertensive ke loaʻa i ka dizziness, ka luhi a me ka ihu koko.ʻO kekahi poʻe maʻi me ke koko systolic o 200mmHg a i luna paha ʻaʻole i ʻike maopopo ʻia nā hōʻike lapaʻau, akā ua pōʻino ko lākou puʻuwai, lolo, puʻupaʻa a me nā kīʻaha koko i kekahi ʻano.Ke holomua nei ka maʻi, e hiki mai ana nā maʻi weliweli e like me ka puʻuwai puʻuwai, myocardial infarction, cerebral hemorrhage, cerebral infarction, renal insufficiency, uremia, a me peripheral vascular occlusion.
(1) ʻO ke kiʻekiʻe kiʻekiʻe nui: pili i ka 90-95% o nā maʻi hypertensive.Hiki ke pili i nā mea he nui e like me nā kumu genetic, ka nohona, ka momona, ke kaumaha a me ka makahiki.
(2) ʻO ke kiʻekiʻe kiʻekiʻe o ke kiʻekiʻe kiʻekiʻe: aia ma kahi o 5-10% o nā maʻi hypertensive.ʻO ia ka piʻi ʻana o ke kahe koko i hoʻokumu ʻia e nā maʻi ʻē aʻe a i ʻole nā lāʻau lapaʻau, e like me ka maʻi kīkī, nā maʻi endocrine, nā maʻi cardiovascular, nā hopena ʻaoʻao lāʻau, etc.
03 ʻO ka lāʻau lapaʻau no nā maʻi hypertension
ʻO nā loina lapaʻau o ka hypertension: ʻo ka lawe ʻana i ka lāʻau no ka manawa lōʻihi, ka hoʻoponopono ʻana i ke kiʻekiʻe o ke koko, hoʻomaikaʻi i nā hōʻailona, ka pale ʻana a me ka mālama ʻana i nā pilikia, a me nā mea ʻē aʻe. ʻO ka hoʻohana lōʻihi ʻana i nā lāʻau antihypertensive ka mea nui o ka mālama ʻana.
Koho maʻamau ka poʻe kauka lapaʻau i ka hui pū ʻana o nā lāʻau like ʻole e pili ana i ke kiʻekiʻe o ke koko a me ka nui o ka pilikia cardiovascular o ka mea maʻi, a hoʻohui i ka lāʻau lapaʻau e hoʻokō pono ai i ke kahe koko.ʻO nā lāʻau antihypertensive i hoʻohana mau ʻia e nā maʻi, ʻo ia ka angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), β-blockers, calcium channel blockers (CCB), a me nā diuretics.
04 ʻO ka hoʻāʻo genetic no ka hoʻohana ʻana i ka lāʻau lapaʻau i nā maʻi hypertensive
I kēia manawa, hoʻohana mau ʻia nā lāʻau antihypertensive i hoʻohana mau ʻia i ka hoʻomaʻamaʻa lapaʻau maʻamau i nā ʻokoʻa pilikino, a ʻo ka hopena curative o nā lāʻau hypertension e pili nui ʻia me nā genetic polymorphisms.Hiki i ka Pharmacogenomics ke wehewehe i ka pilina ma waena o ka pane ʻana o kēlā me kēia kanaka i nā lāʻau lapaʻau a me ka hoʻololi ʻana o ka genetic, e like me ka hopena curative, ka pae dosage a me nā hopena ʻino.Hiki i nā kauka ke ʻike i nā pahuhopu gene e pili ana i ka hoʻoponopono ʻana i ke koko i nā mea maʻi ke kōkua i ka hoʻohālikelike ʻana i ka lāʻau lapaʻau.
No laila, hiki i ka ʻike ʻana i nā gene polymorphism pili i ka lāʻau ke hāʻawi i nā hōʻike genetic kūpono no ke koho ʻana i nā ʻano lāʻau kūpono a me nā ʻano lāʻau lapaʻau, a hoʻomaikaʻi i ka palekana a me ka pono o ka hoʻohana ʻana i ka lāʻau.
05 Ka heluna kanaka pili no ka ho'āʻo genetic o ka lāʻau hoʻokahi no ka hypertension
(1) ʻO nā maʻi me ka hypertension
(2) Ka poʻe me ka mōʻaukala ʻohana o ka hypertension
(3) Ka poʻe i loaʻa nā hopena lāʻau ʻino
(4) Ka poʻe me ka maikaʻi ʻole o ka lāʻau lapaʻau
(5) Pono nā kānaka e lawe i nā lāʻau he nui i ka manawa like
06 Hoʻonā
Ua hoʻomohala ʻo Macro & Micro-Test i nā pahu ʻike fluorescence he nui no ke alakaʻi ʻana a me ka ʻike ʻana i ka lāʻau lapaʻau hypertension, e hāʻawi ana i kahi hopena holoʻokoʻa a piha no ke alakaʻi ʻana i ka lāʻau lapaʻau pilikino a me ka loiloi ʻana i ka hopena o nā hopena lāʻau koʻikoʻi.
Hiki i ka huahana ke ʻike i 8 gene loci e pili ana i nā lāʻau antihypertensive a me 5 mau papa nui o nā lāʻau lapaʻau (B adrenergic receptor blockers, angiotensin II receptor antagonists, angiotensin converting enzyme inhibitors, Calcium antagonists a me diuretics), kahi mea hana nui e hiki ke alakaʻi i ka lāʻau lapaʻau pilikino. a loiloi i ka pilikia o nā hopena lāʻau koʻikoʻi koʻikoʻi.Ma ka ʻike ʻana i nā enzyme metabolizing lāʻau a me nā genes target drug, hiki ke alakaʻi ʻia nā kauka e koho i nā lāʻau antihypertensive kūpono a me ke ʻano no nā maʻi kūikawā, a hoʻomaikaʻi i ka pono a me ka palekana o ka lāʻau lapaʻau antihypertensive.
Maʻalahi e hoʻohana: me ka hoʻohana ʻana i ka ʻenehana hoʻoheheʻe ʻana, hiki i nā pūnāwai hopena 2 ke ʻike i nā pūnaewele 8.
ʻIke kiʻekiʻe: ʻo ka palena haʻahaʻa haʻahaʻa loa he 10.0ng/μL.
Ka pololei kiʻekiʻe: Ua ho'āʻoʻia he 60 mau hōʻailona, a ua kūlike nā pūnaewele SNP o kēlā me kēia gene me nā hualoaʻa o ka hanauna hou a iʻole ka hanauna mua, a he 100%.
Nā hualoaʻa hilinaʻi: Hiki i ka mana o ka maikaʻi maʻamau ke nānā i ke kaʻina ʻike holoʻokoʻa.
Ka manawa hoʻouna: Mei-17-2023