MTHFR Gene Polymorphic Nucleic Acid

ʻO ka ʻakika Folic kahi huaʻai hiki ke hoʻoheheʻe ʻia i ka wai he cofactor pono i nā ala metabolic o ke kino.I nā makahiki i hala iho nei, ua hōʻoia ka nui o nā haʻawina, ʻo ka mutation o ka folate metabolizing enzyme gene MTHFR e alakaʻi i ka hemahema o ka waikawa folic i loko o ke kino, a ʻo ka pōʻino maʻamau o ka nele o ka folic acid i nā pākeke ke kumu i ka anemia megaloblastic, vascular. endothelial pōʻino, etc. ʻAʻole hiki i ka nele o ka waikawa folic i nā wahine hāpai ke hoʻokō i nā pono o lākou iho a me ka ʻōpū, hiki ke hoʻopilikia i ka neural tube, anencephaly, hānau keiki, a me ka hāʻule ʻole.Hoʻopili ʻia nā pae serum folate e 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms.ʻO nā hoʻololi 677C>T a me 1298A>C i loko o ka MTHFR gene e hoʻohuli i ka hoʻololi ʻana o ka alanine i valine a me ka glutamic acid, kēlā me kēia, ka hopena o ka hana MTHFR a hoʻemi i ka hoʻohana ʻana i ka waikawa folic.